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ZRANB3 Antikörper (AA 818-1077)

ZRANB3 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6150540
  • Target Alle ZRANB3 Produkte
    ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    AA 818-1077
    Reaktivität
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 9
    Kaninchen
    Klonalität
    • 9
    Polyklonal
    Konjugat
    • 5
    • 2
    • 1
    • 1
    Dieser ZRANB3 Antikörper ist unkonjugiert
    Applikation
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:1000 - 1:3000
    Kommentare

    HIGH QUALITY

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

  • Target
    ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
    Andere Bezeichnung
    ZRANB3 (ZRANB3 Produkte)
    Synonyme
    4933425L19Rik antikoerper, AH2 antikoerper, AI316834 antikoerper, C730006D09 antikoerper, zinc finger RANBP2-type containing 3 antikoerper, zinc finger, RAN-binding domain containing 3 antikoerper, ZRANB3 antikoerper, Zranb3 antikoerper
    Hintergrund
    DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3
    Molekulargewicht
    42 kDa/49 kDa/67 kDa/123 kDa
    Gen-ID
    84083
    UniProt
    Q5FWF4
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