SIRT2 Antikörper (C-Term)

Produktnummer ABIN615066

Dieses Anti-SIRT2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIRT2 in WB, IHC (p) und EIA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für SIRT2 Antikörper (C-Term) (ABIN615066)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-SIRT2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects SIRT2 / SIR2 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: SIRT2 antibody was raised against 19 amino acid peptide near the carboxy terminus of the Human SIRT2 Genename: SIRT2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Andere Bezeichnung: SIRT2 / SIR2

Hintergrund: The founding member of the sirtuin protein family was the silent information regulator 2 protein (Sir2p) of Saccharomyces cervisiae, an NAD+-dependent histone deacetylase (HDAC) that regulates chromatin silencing. The SIR2 family of genes are highly conserved from prokaryotes to eukaryotes. Mammals have seven homologs of Sir2p, SIRT1-7, which are involved in diverse processes ranging from transcriptional regulation, cell cycle progression and DNA-damage repair to aging. SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules and can deacetylate ?-tubulin and regulate progression through the cell cycle. Most Sirtuins are highly expressed in brain and testis, while Sirt2 expression is higher in fetal relative to adult brain. Recent studies on SIRT2 support the therapeutic utility of inhibitors for the treatment of neurodegenerative diseases such as Parkinson's disease.Synonyms: NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, SIR2L, SIR2L2, SIRT-2, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), sirtuin 2, sirtuin type 2, sirtuin-2

Gen-ID: 22933

NCBI Accession: NP_036369

UniProt: Q8IXJ6