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Melanoma Marker Antikörper (CF®568)

Reaktivität: Human IHC, IF Wirt: Maus Monoclonal KBA-62 CF®568
Produktnummer ABIN6157153
  • Target Alle Melanoma Marker Produkte
    Melanoma Marker
    Reaktivität
    • 48
    • 10
    • 10
    Human
    Wirt
    • 48
    Maus
    Klonalität
    • 48
    Monoklonal
    Konjugat
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser Melanoma Marker Antikörper ist konjugiert mit CF®568
    Applikation
    • 29
    • 18
    • 18
    • 18
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Verwendungszweck
    Mouse Monoclonal anti-Melanoma Marker (KBA.62), CF568 Conjugate
    Produktmerkmale
    KBA.62 is a novel anti-melanoma antibody. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, it reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. KBA.62 antibody is useful in identifying malignant melanomas. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, sarcomas, spindle cell carcinomas and various types of mesenchymal neoplasms. A keratin-negative, vimentin-rich neoplasm that immuno-reacts with antibody to S-100 protein and with KBA.62 antibody is, with rare exception, a melanoma. Anti-KBA.62 is a useful additional marker for melanoma, specifically in desmoplastic/spindle cell cases and in the context of micro-metastasis in sentinel lymph node. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogen
    Human KAL cells derived from lymph node metastasis of malignant melanoma
    Klon
    KBA-62
    Isotyp
    IgG1 kappa
  • Applikationshinweise
    Immunohistology (formalin)
    • Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes
    • Immunofluorescence 0.5-1 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Kommentare

    SK-MEL-13 and SK-MEL-19 Melanoma cell lines, Melanomas

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from light
  • Target
    Melanoma Marker
    Abstract
    Melanoma Marker Produkte
    Hintergrund
    Human Melanoma Associated Antigen, KBA.62
    Molekulargewicht
    Multiple (140, 135 and 128 kDa and two weak bands of 88 and 73 kDa)
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