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CHEK2 Antikörper (AA 514-518)
CHEK2
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-CHEK2 Antikörper
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Target
Alle CHEK2 Antikörper anzeigen
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Bindungsspezifität
Alle Epitope für CHEK2 Antikörper
AA 514-518
Reaktivität
Alle Reaktivitäten für CHEK2 Antikörper
Human
Wirt
Alle Wirte für CHEK2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für CHEK2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für CHEK2 Antikörper
Dieser CHEK2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CHEK2 Antikörper
Western Blotting (WB)
Sequenz
Q-P-S-T-S
Spezifität
This antibody detects endogenous levels of total Chk2 protein.
Kreuzreaktivität (Details)
Species reactivity (tested):Human
Aufreinigung
Affinity-chromatography using epitope-specific peptide
Immunogen
Peptide sequence around aa 514~518 derived from Chk2
Top Product
Discover our top product CHEK2 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1.0 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store (in aliquots) at -20 °C.
Details zu CHEK2
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Target
CHEK2
(Checkpoint Kinase 2 (CHEK2))
Andere Bezeichnung
CHK2 (CHEK2 Produkte )
Synonyme
CDS1 antikoerper, CHK2 antikoerper, HuCds1 antikoerper, LFS2 antikoerper, PP1425 antikoerper, RAD53 antikoerper, hCds1 antikoerper, fa66f08 antikoerper, wu:fa66f08 antikoerper, zgc:55865 antikoerper, Cds1 antikoerper, HUCDS1 antikoerper, Rad53 antikoerper, Chk2 antikoerper, cds1 antikoerper, chek2 antikoerper, chk2 antikoerper, hucds1 antikoerper, lfs2 antikoerper, pp1425 antikoerper, rad53 antikoerper, checkpoint kinase 2 antikoerper, serine/threonine-protein kinase chk2 antikoerper, checkpoint kinase 2 L homeolog antikoerper, CHEK2 antikoerper, chek2 antikoerper, Chek2 antikoerper, MCYG_07308 antikoerper, chek2.L antikoerper
Hintergrund
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.Synonyms: CHEK-2, CHEK2, CHK-2, CHK2 checkpoint homolog, Cds1, RAD53, Serine/threonine-protein kinase Chk2
Molekulargewicht
62 kDa
Gen-ID
11200
NCBI Accession
NP_001005735
UniProt
O96017
Pathways
p53 Signalweg , Apoptose , Zellzyklus
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