NPY1R Antikörper (AA 356-382)

Produktnummer ABIN617932

Produktdetails anti-NPY1R Antikörper

Target: NPY1R (Neuropeptide Y Receptor 1 (NPY1R))

Bindungsspezifität: AA 356-382

Reaktivität: Human, Ratte, Maus, Hamster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPY1R Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunoelectron Microscopy (IEM), Immunocytochemistry (ICC), Immunohistochemistry (IHC)

Kreuzreaktivität: Meerschweinchen, Human, Maus, Ratte (Rattus)

Produktmerkmale: The Neuropeptide Y Y1 Receptor was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat cortex, arcuate and hippocampus using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions are 1/500 - 1/1000 in PBS - Bn/Av-HRP detection. The antibody was characterized by immunohistochemistry and Western blot. Western blot showed one immunoreactive band of 40 kD and a single high molecular weight band, presumably a precursor molecule. Preincubation of the antibody with an excess of the synthetic peptide blocked staining. Immunohistochemical staining of rat brain correlates well with Northern analysis, in situ hybridization and receptor autoradiography. BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human NPY Y1 receptors.

Aufreinigung: Affinity Purified

Immunogen: Rat NPY Y1 receptor (356-382)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Contains ≤ 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: After reconstitution, use immediately or refrigerate at 2 - 8 °C up to 2 days. For long-term storage aliquot antibody and freeze at -15 °C or lower. Avoid repeated freeze/thaw cycles.

Referenzen für anti-NPY1R Antikörper (ABIN617932)

Dubois, Ramamoorthy, Whim, Liu: "Activation of NPY type 5 receptors induces a long-lasting increase in spontaneous GABA release from cerebellar inhibitory interneurons." in: Journal of neurophysiology, Vol. 107, Issue 6, pp. 1655-65, (2012) (PubMed).

Klenke, Constantin, Wray: "Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors." in: Endocrinology, Vol. 151, Issue 6, pp. 2736-46, (2010) (PubMed).

Killough, Lundy, Irwin: "Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y." in: International endodontic journal, Vol. 43, Issue 10, pp. 835-42, (2010) (PubMed).

Dailey, Bartness: "Arcuate nucleus destruction does not block food deprivation-induced increases in food foraging and hoarding." in: Brain research, Vol. 1323, pp. 94-108, (2010) (PubMed).

El Karim, Lamey, Linden, Lundy: "Neuropeptide Y Y1 receptor in human dental pulp cells of noncarious and carious teeth." in: International endodontic journal, Vol. 41, Issue 10, pp. 850-5, (2008) (PubMed).

Gibbs, Diogenes, Hargreaves: "Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors." in: British journal of pharmacology, Vol. 150, Issue 1, pp. 72-9, (2007) (PubMed).

Zhang, Ossipov, Zhang, Lai, Porreca: "Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons." in: Pain, Vol. 129, Issue 1-2, pp. 143-54, (2007) (PubMed).

Dimitrov, DeJoseph, Brownfield, Urban: "Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity." in: Endocrinology, Vol. 148, Issue 8, pp. 3666-73, (2007) (PubMed).

Urban, Leitermann, DeJoseph, Somponpun, Wolak, Sladek: "Influence of dehydration on the expression of neuropeptide Y Y1 receptors in hypothalamic magnocellular neurons." in: Endocrinology, Vol. 147, Issue 9, pp. 4122-31, (2006) (PubMed).

Li, Ritter: "Functional expression of neuropeptide Y receptors in human neuroblastoma cells." in: Regulatory peptides, Vol. 129, Issue 1-3, pp. 119-24, (2005) (PubMed).

Mills, Sohn, Micevych: "Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 4, pp. 947-55, (2004) (PubMed).

Hiruma, Saito, Kusakabe, Takenaka, Kawakami: "Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells." in: The Journal of physiology, Vol. 543, Issue Pt 1, pp. 85-97, (2002) (PubMed).

Details zu NPY1R

Target: NPY1R (Neuropeptide Y Receptor 1 (NPY1R))

Andere Bezeichnung: Neuropeptide Y receptor 1 (NPY1R Produkte)

Hintergrund: Other Names:
Neuropeptide Y receptor 1,NPY receptor 1, NPYR, NPYY1,NPY1-R,Neuropeptide Y receptor type 1, FC5, Npy1r,neuropeptide Y1 receptor, NPY1

Pathways: Feeding Behaviour