MAML2 Antikörper (CF®647)
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- Target Alle MAML2 Antikörper anzeigen
- MAML2 (Mastermind-Like 2 (MAML2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MAML2 Antikörper ist konjugiert mit CF®647
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunostaining (ISt)
- Verwendungszweck
- Mouse Monoclonal anti-MAML2 (MAML2/1302), CF647 Conjugate
- Produktmerkmale
- MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J?, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- Recombinant human full-length MAML2
- Klon
- MAML2-1302
- Isotyp
- IgG2a
- Top Product
- Discover our top product MAML2 Primärantikörper
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- Applikationshinweise
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Immunohistology (formalin) 0.5-1 μg/mL
- Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA pH 9.0 for 10-20 min followed by cooling at RT for 20 min
- Immunofluorescence 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Western blotting 0.5-1 μg/mL
- Optimal dilution for a specific application should be determined by user
- Kommentare
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MCF-7 cells. Pancreas or Placenta. Bladder or Colon Carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Protect from light
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- Target
- MAML2 (Mastermind-Like 2 (MAML2))
- Andere Bezeichnung
- MAML2 (MAML2 Produkte)
- Synonyme
- 5930431H10 antikoerper, BC032967 antikoerper, MAM-3 antikoerper, MAM2 antikoerper, MAM3 antikoerper, MLL-MAML2 antikoerper, mastermind like 2 (Drosophila) antikoerper, mastermind-like transcriptional coactivator 2 antikoerper, mastermind like transcriptional coactivator 2 antikoerper, Maml2 antikoerper, MAML2 antikoerper
- Hintergrund
- Mam-2, MAML2, Mastermind-like protein 2
- Molekulargewicht
- 125 kDa
- Gen-ID
- 84441
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