DcR2 Antikörper (AA 1-210) (APC)
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- Target Alle DcR2 (TNFRSF10D) Antikörper anzeigen
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
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Bindungsspezifität
- AA 1-210
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser DcR2 Antikörper ist konjugiert mit APC
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- The antibody TRAIL-R4-01 reacts with an extracellular epitope of TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- TRAIL-R4 (aa 1-210) - hIgGhc fusion protein
- Klon
- TRAIL-R4-01
- Isotyp
- IgG1
- Top Product
- Discover our top product TNFRSF10D Primärantikörper
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
- Kommentare
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.1 mg/mL
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- Target
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
- Andere Bezeichnung
- CD264 / TRAIL-R4 (TNFRSF10D Produkte)
- Synonyme
- TNFRSF10D antikoerper, CD264 antikoerper, DCR2 antikoerper, TRAIL-R4 antikoerper, TRAILR4 antikoerper, TRUNDD antikoerper, TNF receptor superfamily member 10d antikoerper, tumor necrosis factor receptor superfamily member 10D antikoerper, TNFRSF10D antikoerper, LOC716901 antikoerper
- Hintergrund
- TNF receptor superfamily member 10d,TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).,TNFRSF10D, DcR2, TRUNDD, TRAILR4
- Gen-ID
- 8793
- UniProt
- Q9UBN6
- Pathways
- Apoptose
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