H2AFX Antikörper (pSer139)
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- Target Alle H2AFX Antikörper anzeigen
- H2AFX (H2A Histone Family, Member X (H2AFX))
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Bindungsspezifität
- pSer139
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser H2AFX Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC)
- Immunogen
- Recombinant Protein
- Top Product
- Discover our top product H2AFX Primärantikörper
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- Applikationshinweise
- WB: 1:2000. ICC: 1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Lagerung
- 4 °C,-20 °C
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- Target
- H2AFX (H2A Histone Family, Member X (H2AFX))
- Andere Bezeichnung
- Histone H2A.X (H2AFX Produkte)
- Hintergrund
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
- UniProt
- P16104
- Pathways
- Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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