beta Catenin Antikörper (pSer33, pSer37)

Produktnummer ABIN6241068

Produktdetails anti-beta Catenin Antikörper

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Bindungsspezifität: AA 19-41, pSer33, pSer37

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser beta Catenin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, Zf, M, Rat, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Phospho-beta-catenin (Ser33/37) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 19-41 amino acids from human beta-catenin .

Klon: RB42029

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-beta Catenin Antikörper (ABIN6241068)

Zhuang, Wang, Wang, Ma, Han, Zou, Wu, Dong, Qu, Zang, Wu: "MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma." in: Cell death & disease, Vol. 8, Issue 5, pp. e2804, (2018) (PubMed).

Details zu beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Andere Bezeichnung: beta-catenin (CATNB Produkte)

Synonyme: Bfc antikoerper, Catnb antikoerper, Mesc antikoerper, CTNNB antikoerper, MRD19 antikoerper, armadillo antikoerper, ctnnb antikoerper, id:ibd2058 antikoerper, wu:fb73e10 antikoerper, wu:fi81c06 antikoerper, wu:fk25h01 antikoerper, beta-catenin antikoerper, ctnnb1 antikoerper, CHBCAT antikoerper, catenin (cadherin associated protein), beta 1 antikoerper, catenin beta 1 antikoerper, catenin (cadherin-associated protein), beta 1 antikoerper, catenin beta 1 L homeolog antikoerper, Ctnnb1 antikoerper, CTNNB1 antikoerper, ctnnb1 antikoerper, ctnnb1.L antikoerper

Hintergrund: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:< a href="http://www.uniprot.org/citations/17524503" target="_blank">17524503, PubMed:< a href="http://www.uniprot.org/citations/18077326" target="_blank">18077326, PubMed:< a href="http://www.uniprot.org/citations/18086858" target="_blank">18086858, PubMed:< a href="http://www.uniprot.org/citations/18957423" target="_blank">18957423, PubMed:< a href="http://www.uniprot.org/citations/21262353" target="_blank">21262353, PubMed:< a href="http://www.uniprot.org/citations/22647378" target="_blank">22647378, PubMed:< a href="http://www.uniprot.org/citations/22699938" target="_blank">22699938, PubMed:< a href="http://www.uniprot.org/citations/22155184" target="_blank">22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).

Molekulargewicht: 85497

UniProt: P35222

Pathways: Peptide Hormone Metabolism