HGS Antikörper

Produktnummer ABIN6241891

Produktdetails anti-HGS Antikörper

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HGS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: Synthetic Peptide

Anwendungsinformationen

Applikationshinweise: IF: 1:100. WB: 1:1000. IHC: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Details zu HGS

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Andere Bezeichnung: HGS (HGS Produkte)

Synonyme: HRS antikoerper, Hrs antikoerper, fi34f05 antikoerper, zgc:63492 antikoerper, wu:fi34f05 antikoerper, Hgr antikoerper, ZFYVE8 antikoerper, CG2903 antikoerper, Dmel\\CG2903 antikoerper, HRS-2 antikoerper, Vps27 antikoerper, hrs antikoerper, l(2)23AB5 antikoerper, l(2)23Ad antikoerper, l(2)23Ad(Hrs) antikoerper, vps27 antikoerper, hgs antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate antikoerper, HGF-regulated tyrosine kinase substrate antikoerper, Hepatocyte growth factor regulated tyrosine kinase substrate antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antikoerper, HGS antikoerper, Hgs antikoerper, hgs antikoerper, Hrs antikoerper, hgs.L antikoerper

Hintergrund: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

UniProt: O14964

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation