FGFR3 Antikörper (AA 449-482)

Produktnummer ABIN6242233

Produktdetails anti-FGFR3 Antikörper

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Bindungsspezifität: AA 449-482

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Fgfr3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 449-482 amino acids from the Central region of human Mouse Fgfr3.

Klon: RB50590

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Andere Bezeichnung: Fgfr3 (FGFR3 Produkte)

Synonyme: FGFR3 antikoerper, LOC100034114 antikoerper, ACH antikoerper, CD333 antikoerper, CEK2 antikoerper, HSFGFR3EX antikoerper, JTK4 antikoerper, FR3 antikoerper, Fgfr-3 antikoerper, Flg-2 antikoerper, HBGFR antikoerper, Mfr3 antikoerper, sam3 antikoerper, fc27h01 antikoerper, wu:fc27h01 antikoerper, fibroblast growth factor receptor 3 antikoerper, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog antikoerper, FGFR3 antikoerper, fgfr3.S antikoerper, Fgfr3 antikoerper, fgfr3 antikoerper

Hintergrund: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development.

Molekulargewicht: 87758

UniProt: Q61851

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Growth Factor Binding