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PRKAA1/PRKAA2 Antikörper (N-Term)

Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB43852 unconjugated
Produktnummer ABIN6242246
  • Target Alle PRKAA1/PRKAA2 Produkte
    PRKAA1/PRKAA2 (AMPK1/AMPK2)
    Bindungsspezifität
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 14-47, N-Term
    Reaktivität
    • 24
    • 24
    • 24
    • 19
    • 16
    • 4
    • 2
    • 1
    Maus
    Wirt
    • 24
    • 1
    Kaninchen
    Klonalität
    • 24
    • 1
    Polyklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRKAA1/PRKAA2 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 14
    • 13
    • 13
    • 8
    • 6
    • 5
    • 4
    • 4
    • 2
    Western Blotting (WB)
    Homologie
    Rat, H, Pig
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PRKAA1/2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 14-47 amino acids from the N-terminal region of human PRKAA1/2.
    Klon
    RB43852
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    PRKAA1/PRKAA2 (AMPK1/AMPK2)
    Andere Bezeichnung
    PRKAA1/2 (PRKAA1/PRKAA2 Produkte)
    Synonyme
    AMPK antikoerper, AMPK2 antikoerper, AMPKa2 antikoerper, PRKAA antikoerper, Ampk antikoerper, Ampka2 antikoerper, 2310008I11Rik antikoerper, A830082D05 antikoerper, AMPKalpha2 antikoerper, protein kinase AMP-activated catalytic subunit alpha 2 antikoerper, protein kinase, AMP-activated, alpha 2 catalytic subunit antikoerper, PRKAA2 antikoerper, Prkaa2 antikoerper
    Hintergrund
    Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE, regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU, however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
    Molekulargewicht
    64009
    UniProt
    Q13131
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