IL1RAP Antikörper (AA 484-518)

Produktnummer ABIN6242410

Produktdetails anti-IL1RAP Antikörper

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Bindungsspezifität: AA 484-518

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 484-518 amino acids of human IL1RAP.

Klon: RB57769

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Andere Bezeichnung: IL1RAP (IL1RAP Produkte)

Synonyme: IL1RAP antikoerper, il-1racp antikoerper, il-racp antikoerper, il1r3 antikoerper, C3orf13 antikoerper, IL-1RAcP antikoerper, IL1R3 antikoerper, 6430709H04Rik antikoerper, AI255955 antikoerper, AV239853 antikoerper, IL-1RAcp antikoerper, Il1racpb antikoerper, interleukin 1 receptor accessory protein antikoerper, IL1RAP antikoerper, il1rap antikoerper, il-1racp antikoerper, Il1rap antikoerper

Hintergrund: Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Molekulargewicht: 65418

UniProt: Q9NPH3

Pathways: NF-kappaB Signalweg, Growth Factor Binding