IL-11 Antikörper (AA 27-61)

Produktnummer ABIN6242412

Der Kaninchen Polyklonal Anti-IL-11-Antikörper wurde für WB und FACS validiert. Er ist geeignet, IL-11 in Proben von Human zu detektieren.

Kurzübersicht für IL-11 Antikörper (AA 27-61) (ABIN6242412)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: RB56890

Produktdetails anti-IL-11 Antikörper

Bindungsspezifität: AA 27-61

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IL11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-61 amino acids from human IL11.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu IL-11

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Andere Bezeichnung: IL11

Hintergrund: Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:< a href="http://www.uniprot.org/citations/2145578" target="_blank">2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:< a href="http://www.uniprot.org/citations/12919066" target="_blank">12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Molekulargewicht: 21429

UniProt: P20809

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion