XAF1 Antikörper (C-Term)

Produktnummer ABIN6242701

Produktdetails anti-XAF1 Antikörper

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Bindungsspezifität: AA 235-269, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This XAF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-269 amino acids from the C-terminal region of human XAF1.

Klon: RB49525

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu XAF1

Target: XAF1 (XiAP Associated Factor 1 (XAF1))

Andere Bezeichnung: XAF1 (XAF1 Produkte)

Synonyme: BIRC4BP antikoerper, HSXIAPAF1 antikoerper, XIAPAF1 antikoerper, Fbxo39 antikoerper, XIAP associated factor 1 antikoerper, xaf1 antikoerper, XAF1 antikoerper, Xaf1 antikoerper

Hintergrund: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

Molekulargewicht: 34626

UniProt: Q6GPH4