CYLD Antikörper (AA 305-582)

Produktnummer ABIN6242844

Produktdetails anti-CYLD Antikörper

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Bindungsspezifität: AA 305-582

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYLD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CYLD antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 305-582 amino acids from human CYLD.

Klon: 1667CT857-3-6-1

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu CYLD

Target: CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))

Andere Bezeichnung: CYLD (CYLD Produkte)

Synonyme: BRSS antikoerper, CDMT antikoerper, CYLD1 antikoerper, CYLDI antikoerper, EAC antikoerper, MFT antikoerper, MFT1 antikoerper, SBS antikoerper, TEM antikoerper, USPL2 antikoerper, 2010013M14Rik antikoerper, 2900009M21Rik antikoerper, C130039D01Rik antikoerper, mKIAA0849 antikoerper, cyld antikoerper, LRRGT00003 antikoerper, Rp1 antikoerper, Rp1h antikoerper, CYLD lysine 63 deubiquitinase antikoerper, cylindromatosis (turban tumor syndrome), a antikoerper, CYLD antikoerper, Cyld antikoerper, cylda antikoerper

Hintergrund: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917689" target="_blank">12917689, PubMed:< a href="http://www.uniprot.org/citations/12917691" target="_blank">12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/12917690" target="_blank">12917690). Negative regulator of Wnt signaling (PubMed:< a href="http://www.uniprot.org/citations/20227366" target="_blank">20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:< a href="http://www.uniprot.org/citations/18222923" target="_blank">18222923, PubMed:< a href="http://www.uniprot.org/citations/20194890" target="_blank">20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:< a href="http://www.uniprot.org/citations/17495026" target="_blank">17495026, PubMed:< a href="http://www.uniprot.org/citations/19893491" target="_blank">19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:< a href="http://www.uniprot.org/citations/18636086" target="_blank">18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane, this process does not depend on NF-kappa-B activation (By similarity).

Molekulargewicht: 107316

UniProt: Q9NQC7

Pathways: Apoptose, Activation of Innate immune Response