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PPP6C Antikörper (C-Term)

PPP6C Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB5867 unconjugated
Produktnummer ABIN6242920
  • Target Alle PPP6C Antikörper anzeigen
    PPP6C (Protein Phosphatase 6, Catalytic Subunit (PPP6C))
    Bindungsspezifität
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 275-305, C-Term
    Reaktivität
    • 43
    • 10
    • 9
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 37
    • 3
    • 3
    Kaninchen
    Klonalität
    • 40
    • 3
    Polyklonal
    Konjugat
    • 24
    • 5
    • 4
    • 4
    • 3
    • 3
    Dieser PPP6C Antikörper ist unkonjugiert
    Applikation
    • 35
    • 28
    • 9
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M, Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-305 amino acids from the C-terminal region of human PPP6C.
    Klon
    RB5867
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Williams, Filter, Blake-Hodek, Wadzinski, Fuda, Shalloway, Goldberg: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).

  • Target
    PPP6C (Protein Phosphatase 6, Catalytic Subunit (PPP6C))
    Andere Bezeichnung
    PPP6C (PPP6C Produkte)
    Synonyme
    PP6 antikoerper, PP6C antikoerper, 2310003C10Rik antikoerper, zgc:56227 antikoerper, ppp6c antikoerper, PPP6C antikoerper, pp6 antikoerper, MGC114734 antikoerper, DDBDRAFT_0168786 antikoerper, DDBDRAFT_0185210 antikoerper, DDB_0168786 antikoerper, DDB_0185210 antikoerper, CG12217 antikoerper, DmPpV-6A antikoerper, Dmel\\CG12217 antikoerper, PPPV6A antikoerper, PPV antikoerper, PPV 6A antikoerper, Ppv antikoerper, dPP6 antikoerper, protein phosphatase 6 catalytic subunit antikoerper, protein phosphatase 6, catalytic subunit antikoerper, protein phosphatase 6, catalytic subunit L homeolog antikoerper, serine/threonine-protein phosphatase 6 catalytic subunit antikoerper, Protein phosphatase V antikoerper, PPP6C antikoerper, Ppp6c antikoerper, ppp6c antikoerper, ppp6c.L antikoerper, ppp6C antikoerper, PpV antikoerper
    Hintergrund
    PPP6C belongs to the PPP phosphatase family, PP-V subfamily. Reversible phosphorylation of proteins on serine and threonine residues is an important biochemical event that regulates a broad variety of intracellular processes. The phosphorylation state is determined by the well-controlled balance of activities of serine/threonine-specific protein kinases and protein phosphatases, including PPP6C. Expression levels are highest in testis, heart, and skeletal muscle and lowest in placenta, lung, and kidney. PPP6C can complement mutations in the S. cerevisiae Sit4 and S. pombe ppe1 genes, indicating that PPP6C is the functional homolog of yeast Sit4p and ppe1. Since Sit4p is required for the G1 to S transition of the cell cycle and ppe1 is involved in cell shape control and mitotic division, it has been suggested that PPP6C functions in cell cycle regulation.
    Molekulargewicht
    35144
    NCBI Accession
    NP_001116827, NP_001116841, NP_002712
    UniProt
    O00743
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