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SREBF chaperone Antikörper (N-Term)

SCAP Reaktivität: Human WB Wirt: Maus Monoclonal 1992C245-37-16 unconjugated
Produktnummer ABIN6243003
  • Target Alle SREBF chaperone (SCAP) Antikörper anzeigen
    SREBF chaperone (SCAP)
    Bindungsspezifität
    • 15
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 49-83, N-Term
    Reaktivität
    • 27
    • 18
    • 17
    • 1
    Human
    Wirt
    • 41
    • 1
    Maus
    Klonalität
    • 41
    • 1
    Monoklonal
    Konjugat
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SREBF chaperone Antikörper ist unkonjugiert
    Applikation
    • 33
    • 13
    • 13
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.
    Klon
    1992C245-37-16
    Isotyp
    IgG1 kappa
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  • Applikationshinweise
    WB: 1:4000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    SREBF chaperone (SCAP)
    Andere Bezeichnung
    SCAP (SCAP Produkte)
    Synonyme
    9530044G19 antikoerper, mKIAA0199 antikoerper, SREBF chaperone antikoerper, SREBF chaperone S homeolog antikoerper, SCAP antikoerper, Scap antikoerper, scap.S antikoerper
    Hintergrund
    Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
    Molekulargewicht
    139729
    UniProt
    Q12770
    Pathways
    SARS-CoV-2 Protein Interaktom
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