SREBF chaperone Antikörper (N-Term)

Produktnummer ABIN6243003

Produktdetails anti-SREBF chaperone Antikörper

Target: SREBF chaperone (SCAP)

Bindungsspezifität: AA 49-83, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SREBF chaperone Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.

Klon: 1992C245-37-16

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SREBF chaperone

Target: SREBF chaperone (SCAP)

Andere Bezeichnung: SCAP (SCAP Produkte)

Synonyme: 9530044G19 antikoerper, mKIAA0199 antikoerper, SREBF chaperone antikoerper, SREBF chaperone S homeolog antikoerper, SCAP antikoerper, Scap antikoerper, scap.S antikoerper

Hintergrund: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

Molekulargewicht: 139729

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interaktom