PPID Antikörper (AA 336-370)

Produktnummer ABIN6243007

Produktdetails anti-PPID Antikörper

Target: PPID (Peptidylprolyl Isomerase D (PPID))

Bindungsspezifität: AA 336-370

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPID Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Cyclophilin D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 336-370 amino acids from the human region of human Cyclophilin D.

Klon: RB55961

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:2000. IHC-P: 1:25. FC: 1:25. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu PPID

Target: PPID (Peptidylprolyl Isomerase D (PPID))

Andere Bezeichnung: Cyclophilin D (PPID Produkte)

Synonyme: PPID antikoerper, CYP-40 antikoerper, CYPD antikoerper, Cyp-40 antikoerper, CypD antikoerper, wu:fb18b07 antikoerper, zgc:86711 antikoerper, 4930564J03Rik antikoerper, Ppidl antikoerper, Ppif antikoerper, cyp-40 antikoerper, cypd antikoerper, peptidylprolyl isomerase D antikoerper, peptidylprolyl isomerase D (cyclophilin D) antikoerper, peptidylprolyl isomerase D (cyclophilin D) S homeolog antikoerper, PPID antikoerper, Ppid antikoerper, ppid antikoerper, ppid.S antikoerper

Hintergrund: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Molekulargewicht: 40764

UniProt: Q08752

Pathways: Nuclear Hormone Receptor Binding