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EHMT2 Antikörper (AA 589-623)

Der Kaninchen Polyklonal Anti-EHMT2-Antikörper wurde für WB validiert. Er ist geeignet, EHMT2 in Proben von Maus zu detektieren.
Produktnummer ABIN6243048

Kurzübersicht für EHMT2 Antikörper (AA 589-623) (ABIN6243048)

Target

Alle EHMT2 Antikörper anzeigen
EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

Reaktivität

  • 46
  • 20
  • 14
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Maus

Wirt

  • 46
  • 2
  • 1
Kaninchen

Klonalität

  • 39
  • 10
Polyklonal

Konjugat

  • 37
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser EHMT2 Antikörper ist unkonjugiert

Applikation

  • 39
  • 17
  • 13
  • 10
  • 7
  • 6
  • 5
  • 5
  • 2
  • 1
  • 1
Western Blotting (WB)

Klon

RB52371
  • Bindungsspezifität

    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 589-623

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This Mouse Ehmt2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 589-623 amino acids from the Central region of Mouse Ehmt2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Target

    EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

    Andere Bezeichnung

    Ehmt2

    Hintergrund

    Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

    Molekulargewicht

    138039

    UniProt

    Q9Z148
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