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BCL6 Antikörper (AA 364-395)

BCL6 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB43648 unconjugated
Produktnummer ABIN6243067
  • Target Alle BCL6 Antikörper anzeigen
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Bindungsspezifität
    • 28
    • 22
    • 11
    • 7
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 364-395
    Reaktivität
    • 131
    • 61
    • 26
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 74
    • 55
    • 2
    • 1
    Kaninchen
    Klonalität
    • 68
    • 64
    Polyklonal
    Konjugat
    • 69
    • 12
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser BCL6 Antikörper ist unkonjugiert
    Applikation
    • 75
    • 47
    • 37
    • 36
    • 32
    • 15
    • 14
    • 11
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This BCL6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 364-395 amino acids from the Central region of human BCL6.
    Klon
    RB43648
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BCL6 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
    Andere Bezeichnung
    BCL6 (BCL6 Produkte)
    Synonyme
    bcl5 antikoerper, laz3 antikoerper, bcl6a antikoerper, znf51 antikoerper, zbtb27 antikoerper, MGC132260 antikoerper, Bcl5 antikoerper, BCL5 antikoerper, BCL6A antikoerper, LAZ3 antikoerper, ZBTB27 antikoerper, ZNF51 antikoerper, B-cell CLL/lymphoma 6 L homeolog antikoerper, B-cell CLL/lymphoma 6 antikoerper, B cell leukemia/lymphoma 6 antikoerper, bcl6.L antikoerper, bcl6 antikoerper, BCL6 antikoerper, Bcl6 antikoerper
    Hintergrund
    Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53- dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH- dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
    Molekulargewicht
    78846
    UniProt
    P41182
    Pathways
    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
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