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FZR1 Antikörper (AA 1-496)

FZR1 Reaktivität: Human WB Wirt: Maus Monoclonal 1621CT637-76-67 unconjugated
Produktnummer ABIN6243204
  • Target Alle FZR1 Antikörper anzeigen
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Bindungsspezifität
    • 15
    • 11
    • 8
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-496
    Reaktivität
    • 61
    • 31
    • 15
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 56
    • 5
    Maus
    Klonalität
    • 56
    • 5
    Monoklonal
    Konjugat
    • 20
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FZR1 Antikörper ist unkonjugiert
    Applikation
    • 44
    • 23
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
    Klon
    1621CT637-76-67
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product FZR1 Primärantikörper
  • Applikationshinweise
    WB: 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Andere Bezeichnung
    FZR (FZR1 Produkte)
    Synonyme
    CDH1-C antikoerper, FYR antikoerper, FZR antikoerper, CDH1 antikoerper, fzr1 antikoerper, CDC20C antikoerper, FZR2 antikoerper, HCDH antikoerper, HCDH1 antikoerper, AW108046 antikoerper, Cdh1 antikoerper, Fyr antikoerper, zgc:55450 antikoerper, fizzy and cell division cycle 20 related 1 antikoerper, fizzy/cell division cycle 20 related 1 antikoerper, fizzy-related protein homolog antikoerper, fizzy/cell division cycle 20 related 1 (Drosophila) antikoerper, fizzy/cell division cycle 20 related 1a antikoerper, Fzr1 antikoerper, CDH1-C antikoerper, FZR1 antikoerper, LOC100027495 antikoerper, LOC100179951 antikoerper, fzr1a antikoerper
    Hintergrund
    Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
    Molekulargewicht
    55179
    UniProt
    Q9UM11
    Pathways
    DNA Replication, Synthesis of DNA
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