This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PIP4K2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-400 amino acids from the C-terminal region of human PIP4K2A.
PI5P4KA antikoerper, PIP5K2A antikoerper, PIP5KII-alpha antikoerper, PIP5KIIA antikoerper, PIPK antikoerper, AW742916 antikoerper, Pip5k2a antikoerper, pipk antikoerper, pi5p4ka antikoerper, pip5k2a antikoerper, pip5kiia antikoerper, pip4k2a antikoerper, zgc:194746 antikoerper, zgc:194777 antikoerper, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha S homeolog antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a antikoerper, PIP4K2A antikoerper, Pip4k2a antikoerper, pip4k2a.S antikoerper, pip4k2a antikoerper, pip4k2aa antikoerper
Hintergrund
Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.