RAPGEF2 Antikörper (C-Term)

Produktnummer ABIN6243297

Produktdetails anti-RAPGEF2 Antikörper

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Bindungsspezifität: AA 1464-1498, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RAPGEF2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1464-1498 amino acids from the C-terminal region of human RAPGEF2.

Klon: RB52925

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RAPGEF2

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Andere Bezeichnung: RAPGEF2 (RAPGEF2 Produkte)

Synonyme: MGC83978 antikoerper, RAPGEF2 antikoerper, fa11h07 antikoerper, wu:fa11h07 antikoerper, CNrasGEF antikoerper, NRAPGEP antikoerper, PDZ-GEF1 antikoerper, PDZGEF1 antikoerper, RA-GEF antikoerper, Rap-GEP antikoerper, nRap GEP antikoerper, 5830453M24Rik antikoerper, CNRasGEF antikoerper, Pdzgef1 antikoerper, RA-GEF-1 antikoerper, mKIAA0313 antikoerper, nRapGEP antikoerper, Rap guanine nucleotide exchange factor 2 antikoerper, Rap guanine nucleotide exchange factor 2 L homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 2 antikoerper, RAPGEF2 antikoerper, rapgef2.L antikoerper, rapgef2 antikoerper, Rapgef2 antikoerper

Hintergrund: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:< a href="http://www.uniprot.org/citations/23800469" target="_blank">23800469, PubMed:< a href="http://www.uniprot.org/citations/10801446" target="_blank">10801446) or not (PubMed:< a href="http://www.uniprot.org/citations/10608844" target="_blank">10608844, PubMed:< a href="http://www.uniprot.org/citations/10548487" target="_blank">10548487, PubMed:< a href="http://www.uniprot.org/citations/11359771" target="_blank">11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP- induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain- derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.

Molekulargewicht: 167417

UniProt: Q9Y4G8

Pathways: Neurotrophin Signalübertragung