GSK3 beta Antikörper (N-Term)

Produktnummer ABIN6243417

Produktdetails anti-GSK3 beta Antikörper

Target: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Bindungsspezifität: AA 4-34, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSK3 beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GSK3 beta (GSK3B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of human GSK3 beta (GSK3B).

Klon: RB03816

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GSK3 beta Antikörper (ABIN6243417)

Li, Jia, Ren, Liu, Gong, Wang, Zhang, Zhao: "Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma." in: IUBMB life, Vol. 66, Issue 7, pp. 507-18, (2014) (PubMed).

Details zu GSK3 beta

Target: GSK3 beta (GSK3b) (Glycogen Synthase Kinase 3 beta (GSK3b))

Andere Bezeichnung: GSK3 beta (GSK3B) (GSK3b Produkte)

Synonyme: GSK3 antikoerper, GSK-3 antikoerper, C86142 antikoerper, GSK-3beta antikoerper, 7330414F15Rik antikoerper, 8430431H08Rik antikoerper, GSK3beta antikoerper, fk80d11 antikoerper, GSK-3[b] antikoerper, wu:fb68h05 antikoerper, wu:fk80d11 antikoerper, gsk-3 antikoerper, gsk3 antikoerper, gsk3-beta antikoerper, gsk3beta antikoerper, xgsk-3 antikoerper, glycogen synthase kinase 3 beta antikoerper, glycogen synthase kinase 3 beta L homeolog antikoerper, GSK3B antikoerper, Gsk3b antikoerper, gsk3b antikoerper, gsk3b.L antikoerper

Hintergrund: GSK3B, a member of the Ser/Thr protein kinase family, participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. GSK3B phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. The protein is inhibited when phosphorylated by AKT1 or ILK1. Expressed is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney.

Molekulargewicht: 46744

NCBI Accession: NP_001139628, NP_002084

UniProt: P49841

Pathways: WNT Signalweg, Hedgehog Signalweg, Fc-epsilon Rezeptor Signalübertragung, Cellular Glucan Metabolic Process, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Autophagie, BCR Signaling, Warburg Effekt