ITGA7 Antikörper (C-Term)

Produktnummer ABIN6243591

Produktdetails anti-ITGA7 Antikörper

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Bindungsspezifität: AA 1149-1181, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGA7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ITGA7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1149-1181 amino acids from the C-terminal region of human ITGA7.

Klon: RB52832

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:8000. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ITGA7 Antikörper (ABIN6243591)

Ming, Fu, Zhang, Qin, Cao, Chan, Ma, Xie, Guan: "Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma." in: Nature communications, Vol. 7, pp. 13568, (2018) (PubMed).

Details zu ITGA7

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Andere Bezeichnung: ITGA7 (ITGA7 Produkte)

Synonyme: [a]7 antikoerper, alpha7 antikoerper, integrin alpha 7 antikoerper, integrin subunit alpha 7 antikoerper, Itga7 antikoerper, ITGA7 antikoerper

Hintergrund: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

Molekulargewicht: 128948

UniProt: Q13683

Pathways: Integrin Complex