EPH Receptor A4 Antikörper (AA 383-417)

Produktnummer ABIN6243785

Produktdetails anti-EPH Receptor A4 Antikörper

Target: EPH Receptor A4 (EPHA4)

Bindungsspezifität: AA 383-417

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EPHA4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 383-417 amino acids from the Central region of human EPHA4.

Klon: RB50832

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Andere Bezeichnung: EPHA4 (EPHA4 Produkte)

Synonyme: HEK8 antikoerper, SEK antikoerper, TYRO1 antikoerper, RGD1560587 antikoerper, ephe antikoerper, EPHA4 antikoerper, Ci-Eph1 antikoerper, sek antikoerper, hek8 antikoerper, rtk1 antikoerper, tyr01 antikoerper, 2900005C20Rik antikoerper, AI385584 antikoerper, Cek8 antikoerper, Hek8 antikoerper, Sek antikoerper, Sek1 antikoerper, Tyro1 antikoerper, rb antikoerper, XEpha4 antikoerper, sek-1 antikoerper, epha4 antikoerper, pag antikoerper, EphA4 antikoerper, apha3 antikoerper, ek2 antikoerper, epha3 antikoerper, sb:cb246 antikoerper, zek2 antikoerper, zgc:109882 antikoerper, EPH receptor A4 antikoerper, Eph receptor A4 antikoerper, ephrin receptor epsilon antikoerper, EPH receptor A4 S homeolog antikoerper, EPH receptor A4 L homeolog antikoerper, eph receptor A4a antikoerper, EPHA4 antikoerper, Epha4 antikoerper, ephe antikoerper, epha4 antikoerper, epha4.S antikoerper, epha4.L antikoerper, epha4a antikoerper

Hintergrund: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. Beside its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Molekulargewicht: 109860

UniProt: P54764

Pathways: RTK Signalweg