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SMURF2 Antikörper

SMURF2 Reaktivität: Human WB Wirt: Maus Monoclonal 1826CT865-51-28 unconjugated
Produktnummer ABIN6243825
  • Target Alle SMURF2 Antikörper anzeigen
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Reaktivität
    • 66
    • 34
    • 20
    Human
    Wirt
    • 64
    • 2
    Maus
    Klonalität
    • 55
    • 11
    Monoklonal
    Konjugat
    • 19
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMURF2 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 28
    • 24
    • 14
    • 13
    • 13
    • 13
    • 11
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This SMURF2 antibody is generated from a mouse immunized with a recombinant protein of human SMURF2.
    Klon
    1826CT865-51-28
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product SMURF2 Primärantikörper
  • Applikationshinweise
    WB: 1:2000-1:4000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Andere Bezeichnung
    SMURF2 (SMURF2 Produkte)
    Synonyme
    SMURF2 antikoerper, 2810411E22Rik antikoerper, AI558114 antikoerper, AI649275 antikoerper, RGD1310067 antikoerper, wu:fb82a11 antikoerper, wu:fc41c02 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 S homeolog antikoerper, SMURF2 antikoerper, smurf2 antikoerper, Smurf2 antikoerper, smurf2.S antikoerper
    Hintergrund
    E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
    Molekulargewicht
    86196
    UniProt
    Q9HAU4
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