RAD21 Antikörper (AA 501-535)
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- Target Alle RAD21 Antikörper anzeigen
- RAD21 (RAD21 Homolog (RAD21))
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Bindungsspezifität
- AA 501-535
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RAD21 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Homologie
- B
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This RAD21 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 501-535 amino acids from human RAD21.
- Klon
- RB56184
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product RAD21 Primärantikörper
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- Applikationshinweise
- WB: 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Haltbarkeit
- 6 months
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- Target
- RAD21 (RAD21 Homolog (RAD21))
- Andere Bezeichnung
- RAD21 (RAD21 Produkte)
- Hintergrund
- Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
- Molekulargewicht
- 71690
- UniProt
- O60216
- Pathways
- Positive Regulation of Endopeptidase Activity
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