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ITK Antikörper (N-Term)

ITK Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB50676 unconjugated
Produktnummer ABIN6243872
  • Target Alle ITK Antikörper anzeigen
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Bindungsspezifität
    • 14
    • 10
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 156-190, N-Term
    Reaktivität
    • 50
    • 19
    • 12
    • 6
    • 3
    Maus
    Wirt
    • 61
    • 5
    • 2
    Kaninchen
    Klonalität
    • 63
    • 5
    Polyklonal
    Konjugat
    • 29
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITK Antikörper ist unkonjugiert
    Applikation
    • 41
    • 36
    • 14
    • 14
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Homologie
    H
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Itk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 156-190 amino acids from the N-terminal region of human Mouse Itk.
    Klon
    RB50676
    Isotyp
    Ig Fraction
    Top Product
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  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Andere Bezeichnung
    Itk (ITK Produkte)
    Synonyme
    Emt antikoerper, Tcsk antikoerper, Tsk antikoerper, EMT antikoerper, LPFS1 antikoerper, LYK antikoerper, PSCTK2 antikoerper, IL2 inducible T cell kinase antikoerper, IL2 inducible T-cell kinase antikoerper, IL2-inducible T-cell kinase antikoerper, Itk antikoerper, ITK antikoerper
    Hintergrund
    Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
    Molekulargewicht
    72292
    UniProt
    Q03526
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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