MORF4L1 Antikörper (AA 328-360)

Produktnummer ABIN6243887

Produktdetails anti-MORF4L1 Antikörper

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Bindungsspezifität: AA 328-360

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MORF4L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MORF4L1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 328-360 amino acids from human MORF4L1.

Klon: RB54237

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu MORF4L1

Target: MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))

Andere Bezeichnung: MORF4L1 (MORF4L1 Produkte)

Synonyme: Eaf3 antikoerper, HsT17725 antikoerper, MEAF3 antikoerper, MORFRG15 antikoerper, MRG15 antikoerper, S863-6 antikoerper, TEG-189 antikoerper, Tex189 antikoerper, mKIAA4002 antikoerper, MORF4L2 antikoerper, CG6363 antikoerper, DmMRG15 antikoerper, Dmel\\CG6363 antikoerper, Dmrg15 antikoerper, Mrg15 antikoerper, dMRG15 antikoerper, dMrg15 antikoerper, l(3)j6A3 antikoerper, zgc:92289 antikoerper, mortality factor 4 like 1 antikoerper, MORF-related gene 15 antikoerper, MRG15 antikoerper, mortality factor 4 like 1 S homeolog antikoerper, MORF4L1 antikoerper, Morf4l1 antikoerper, MRG15 antikoerper, CpipJ_CPIJ013367 antikoerper, morf4l1.S antikoerper, morf4l1 antikoerper

Hintergrund: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Molekulargewicht: 41474

UniProt: Q9UBU8

Pathways: Chromatin Binding