SNW1 Antikörper (AA 464-497)

Produktnummer ABIN6243922

Produktdetails anti-SNW1 Antikörper

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Bindungsspezifität: AA 464-497

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNW1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SNW1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 464-497 amino acids from human SNW1.

Klon: RB54232

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu SNW1

Target: SNW1 (SNW Domain Containing 1 (SNW1))

Andere Bezeichnung: SNW1 (SNW1 Produkte)

Synonyme: Gle1l1 antikoerper, Skiip antikoerper, bx42 antikoerper, ncoa-62 antikoerper, prp45 antikoerper, prpf45 antikoerper, skiip antikoerper, skip antikoerper, Bx42 antikoerper, NCOA-62 antikoerper, PRPF45 antikoerper, Prp45 antikoerper, SKIIP antikoerper, SKIP antikoerper, 2310008B08Rik antikoerper, AW048543 antikoerper, NCoA-62 antikoerper, SNW domain containing 1 antikoerper, nuclear protein SkiP antikoerper, puff-specific protein Bx42 antikoerper, putative nuclear protein SkiP antikoerper, GLE1 RNA export mediator homolog (yeast), pseudogene 1 antikoerper, SNW domain containing 1 S homeolog antikoerper, snw1 antikoerper, PVX_002605 antikoerper, LOC5564605 antikoerper, Smp_105860 antikoerper, UREG_03916 antikoerper, Gle1-ps1 antikoerper, snw1.S antikoerper, SNW1 antikoerper, Snw1 antikoerper

Hintergrund: Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA, the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Molekulargewicht: 61494

UniProt: Q13573

Pathways: Retinoic Acid Receptor Signaling Pathway