RBX1 Antikörper (AA 1-108)

Produktnummer ABIN6243992

Produktdetails anti-RBX1 Antikörper

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Bindungsspezifität: AA 1-108

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This antibody is generated from a mouse immunized with a recombinant protein between 1-108 amino acids from human.

Klon: 1859CT866-7-47

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:4000. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu RBX1

Target: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Andere Bezeichnung: RBX1 (RBX1 Produkte)

Hintergrund: E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.

Molekulargewicht: 12274

UniProt: P62877

Pathways: Zellzyklus, M Phase, SARS-CoV-2 Protein Interaktom