TRIM24 Antikörper (C-Term)

Produktnummer ABIN6244019

Produktdetails anti-TRIM24 Antikörper

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Bindungsspezifität: AA 789-843, C-Term

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM24 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Trim24 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 789-843 amino acids from the C-terminal region of Mouse Trim24.

Klon: RB51160

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:25. WB: 1:1000. WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu TRIM24

Target: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Andere Bezeichnung: Trim24 (TRIM24 Produkte)

Synonyme: TRIM24 antikoerper, PTC6 antikoerper, RNF82 antikoerper, TF1A antikoerper, TIF1 antikoerper, TIF1A antikoerper, TIF1ALPHA antikoerper, hTIF1 antikoerper, ptc6 antikoerper, rnf82 antikoerper, tf1a antikoerper, tif1 antikoerper, tif1a antikoerper, tif1alpha antikoerper, A130082H20Rik antikoerper, AI447469 antikoerper, D430004I05Rik antikoerper, TIF1-alpha antikoerper, TIF1alpha antikoerper, Tif1a antikoerper, tripartite motif containing 24 antikoerper, transcription intermediary factor 1-alpha antikoerper, tripartite motif containing 24 S homeolog antikoerper, tripartite motif-containing 24 antikoerper, TRIM24 antikoerper, trim24 antikoerper, LOC100548578 antikoerper, trim24.S antikoerper, Trim24 antikoerper

Hintergrund: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.

Molekulargewicht: 116657

UniProt: Q64127