CAMK2B Antikörper (AA 1-503)

Produktnummer ABIN6244287

Produktdetails anti-CAMK2B Antikörper

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Bindungsspezifität: AA 1-503

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CAMK2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This CAMK2 beta antibody is generated from a mouse immunized with a recombinant protein between 1-503 amino acids from human CAMK2 beta.

Klon: 1050CT14-1-3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu CAMK2B

Target: CAMK2B (Calcium/calmodulin-Dependent Protein Kinase II beta (CAMK2B))

Andere Bezeichnung: CAMK2 beta (CAMK2B Produkte)

Synonyme: CAM2 antikoerper, CAMK2 antikoerper, CAMKB antikoerper, Camk2d antikoerper, Ck2b antikoerper, camk2 antikoerper, camk2b antikoerper, cam2 antikoerper, camkb antikoerper, CAMK2B antikoerper, calcium/calmodulin dependent protein kinase II beta antikoerper, calcium/calmodulin-dependent protein kinase II, beta antikoerper, calcium/calmodulin-dependent protein kinase II beta antikoerper, calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog antikoerper, calcium/calmodulin dependent protein kinase (CaM kinase) II beta L homeolog antikoerper, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta antikoerper, CAMK2B antikoerper, Camk2b antikoerper, camk2a.S antikoerper, camk2b.L antikoerper

Hintergrund: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Molekulargewicht: 72678

UniProt: Q13554

Pathways: WNT Signalweg, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity