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MITF Antikörper (pSer73, pSer180)

MITF Reaktivität: Human, Maus, Ratte, Affe WB, IHC, IF, ELISA, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6255037
  • Target Alle MITF Antikörper anzeigen
    MITF (Microphthalmia-Associated Transcription Factor (MITF))
    Bindungsspezifität
    • 17
    • 15
    • 12
    • 8
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer73, pSer180
    Reaktivität
    • 100
    • 49
    • 24
    • 17
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Affe
    Wirt
    • 75
    • 40
    • 1
    Kaninchen
    Klonalität
    • 66
    • 50
    Polyklonal
    Konjugat
    • 63
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MITF Antikörper ist unkonjugiert
    Applikation
    • 67
    • 47
    • 42
    • 34
    • 34
    • 17
    • 13
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
    Spezifität
    Phospho-MITF (Ser180/73) Antibody detects endogenous levels of MITF only when phosphorylated at Serine 180/73
    Kreuzreaktivität
    Human, Affe, Maus, Ratte (Rattus)
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human MITF around the phosphorylation site of Serine 180/73
    Isotyp
    IgG
    Top Product
    Discover our top product MITF Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    MITF (Microphthalmia-Associated Transcription Factor (MITF))
    Andere Bezeichnung
    MITF (MITF Produkte)
    Hintergrund

    Description: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

    Gene: MITF

    Molekulargewicht
    52kDa
    Gen-ID
    4286
    UniProt
    O75030
    Pathways
    Chromatin Binding
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