FANCD2 Antikörper (pSer222)

Produktnummer ABIN6255106

Produktdetails anti-FANCD2 Antikörper

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Bindungsspezifität: pSer222

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-FANCD2 (Ser222) Antibody detects endogenous levels of FANCD2 only when phosphorylated at Serine 222.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human FANCD2 around the phosphorylation site of Ser222.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Andere Bezeichnung: FANCD2 (FANCD2 Produkte)

Synonyme: FANCD2 antikoerper, CG17269 antikoerper, CG31192 antikoerper, CG31194 antikoerper, Dmel\\CG17269 antikoerper, dmFANCD2 antikoerper, xfancd2 antikoerper, FA-D2 antikoerper, FA4 antikoerper, FACD antikoerper, FAD antikoerper, FAD2 antikoerper, FANCD antikoerper, 2410150O07Rik antikoerper, AU015151 antikoerper, BB137857 antikoerper, Fanconi anemia complementation group D2 antikoerper, CG17269 gene product from transcript CG17269-RA antikoerper, Fanconi anemia group D2 protein antikoerper, Fanconi anemia, complementation group D2 antikoerper, Fanconi anemia complementation group D2 L homeolog antikoerper, FANCD2 antikoerper, Fancd2 antikoerper, LOC100455970 antikoerper, fancd2 antikoerper, fancd2.L antikoerper

Hintergrund:

Description: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

Gene: FANCD2

Molekulargewicht: 166kDa

Gen-ID: 2177

UniProt: Q9BXW9

Pathways: DNA Reparatur