IRS1 Antikörper (pSer307)

Produktnummer ABIN6255185

Produktdetails anti-IRS1 Antikörper

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Bindungsspezifität: pSer307

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-IRS-1 (Ser307) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Serine 307

Kreuzreaktivität: Human, Affe, Maus, Ratte (Rattus)

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human IRS-1 around the phosphorylation site of Serine 307

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Referenzen für anti-IRS1 Antikörper (ABIN6255185)

Geng, Zhu, Wang, Xie, Li, Wu, Li, Chen, Wang, Meng, Zhang, Chen, Zhong: "P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways." in: Biochemical and biophysical research communications, Vol. 495, Issue 3, pp. 2139-2144, (2018) (PubMed).

Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhong: "Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells." in: Biomedicine & pharmacotherapy, Vol. 97, pp. 1538-1543, (2018) (PubMed).

Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhu, Wu, Huang, Zhong: "Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways." in: Toxicology letters, Vol. 272, pp. 75-83, (2017) (PubMed).

Details zu IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Andere Bezeichnung: IRS-1 (IRS1 Produkte)

Synonyme: HIRS-1 antikoerper, G972R antikoerper, IRS-1 antikoerper, IRS1IRM antikoerper, irs1 antikoerper, irsu antikoerper, IRS1 antikoerper, irs-1 antikoerper, irs1-a antikoerper, insulin receptor substrate 1 antikoerper, insulin receptor substrate 2 antikoerper, insulin receptor substrate 1 S homeolog antikoerper, IRS1 antikoerper, Irs1 antikoerper, irs2 antikoerper, irs1.S antikoerper

Hintergrund:

Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Gene: IRS1

Molekulargewicht: 180kDa

Gen-ID: 3667

UniProt: P35568

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process