RACGAP1 Antikörper (pSer387)

Produktnummer ABIN6255287

Produktdetails anti-RACGAP1 Antikörper

Target: RACGAP1 (Rac GTPase Activating Protein 1 (RACGAP1))

Bindungsspezifität: pSer387

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RACGAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-GTPase Activating Protein (Ser387) Antibody detects endogenous levels of GTPase Activating Protein only when phosphorylated at Serine 387

Kreuzreaktivität: Human, Affe, Maus, Ratte (Rattus)

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human GTPase Activating Protein around the phosphorylation site of Serine 387

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu RACGAP1

Target: RACGAP1 (Rac GTPase Activating Protein 1 (RACGAP1))

Andere Bezeichnung: GTPase Activating Protein (RACGAP1 Produkte)

Synonyme: CYK4 antikoerper, HsCYK-4 antikoerper, ID-GAP antikoerper, MgcRacGAP antikoerper, cyk-4 antikoerper, id-gap antikoerper, mgcracgap antikoerper, RACGAP1 antikoerper, MGC121578 antikoerper, Gap antikoerper, RasGAP antikoerper, Rasa antikoerper, GAPX antikoerper, AI227039 antikoerper, AI327394 antikoerper, Band25 antikoerper, GTPase antikoerper, gtl11 antikoerper, mKIAA1478 antikoerper, wu:fb92c08 antikoerper, zgc:77839 antikoerper, Rac GTPase activating protein 1 antikoerper, rac GTPase-activating protein 1 antikoerper, Rac GTPase activating protein 1 L homeolog antikoerper, RAS p21 protein activator 1 antikoerper, Rac GTPase-activating protein 1 antikoerper, si:ch1073-416j23.1 antikoerper, RACGAP1 antikoerper, racgap1 antikoerper, racgap1.L antikoerper, racgap1.2.L antikoerper, racgap1.2 antikoerper, Rasa1 antikoerper, Racgap1 antikoerper, si:ch1073-416j23.1 antikoerper

Hintergrund:

Description: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

Gene: RACGAP1

Molekulargewicht: 72kDa

Gen-ID: 29127

UniProt: Q9H0H5

Pathways: Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling of Hepatocyte Growth Factor Receptor