Dynamin 1-Like Antikörper (pSer637)

Produktnummer ABIN6255437

Produktdetails anti-Dynamin 1-Like Antikörper

Target: Dynamin 1-Like (DNM1L)

Bindungsspezifität: pSer637

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dynamin 1-Like Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-DRP1 (Ser637) Antibody detects endogenous levels of DRP1 only when phosphorylated at Ser637.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human DRP1 around the phosphorylation site of Ser637.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Andere Bezeichnung: DNM1L (DNM1L Produkte)

Synonyme: DLP1 antikoerper, DRP1 antikoerper, DVLP antikoerper, DYMPLE antikoerper, EMPF antikoerper, HDYNIV antikoerper, 6330417M19Rik antikoerper, AI450666 antikoerper, Dlp1 antikoerper, Dnmlp1 antikoerper, Drp1 antikoerper, python antikoerper, Dnml1 antikoerper, dnm1l antikoerper, MGC53850 antikoerper, zgc:66163 antikoerper, DNM1L antikoerper, 18.m06247 antikoerper, CG3210 antikoerper, DRP antikoerper, Dmel\CG3210 antikoerper, Dnm1/Drp1 antikoerper, Drp antikoerper, Drp-1 antikoerper, drp-1 antikoerper, drp1 antikoerper, frat antikoerper, l(2)22Fc antikoerper, l(2)22Fd antikoerper, l(2)ND2 antikoerper, l(2)ND3 antikoerper, dynamin 1 like antikoerper, dynamin 1-like antikoerper, dynamin 1-like L homeolog antikoerper, dynamin-1-like antikoerper, dynamin-1-like protein antikoerper, dynamin-like protein antikoerper, Dynamin related protein 1 antikoerper, DNM1L antikoerper, Dnm1l antikoerper, dnm1l.L antikoerper, dnm1l antikoerper, LOC100369408 antikoerper, LOC411472 antikoerper, dyn1 antikoerper, cgd1_580 antikoerper, EHI_052740 antikoerper, PVX_092875 antikoerper, BBOV_II002980 antikoerper, Drp1 antikoerper

Hintergrund:

Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Gene: DNM1L

Molekulargewicht: 82kDa

Gen-ID: 10059

UniProt: O00429