Retinoic Acid Receptor alpha Antikörper (pSer77)

Produktnummer ABIN6255501

Produktdetails anti-Retinoic Acid Receptor alpha Antikörper

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Bindungsspezifität: pSer77

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoic Acid Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-Retinoic Acid Receptor alpha (Ser77) Antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at Sersine 77.

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of Ser77.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Retinoic Acid Receptor alpha

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Andere Bezeichnung: RARA (RARA Produkte)

Synonyme: NR1B1 antikoerper, RAR antikoerper, Nr1b1 antikoerper, RARalpha1 antikoerper, rar-alpha antikoerper, etID309833.12 antikoerper, rara antikoerper, rara2a antikoerper, zRAR antikoerper, zRAR-alpha antikoerper, zgc:109797 antikoerper, nr1b1 antikoerper, RAR-ALPHA1 antikoerper, HS-RARa antikoerper, fj66e06 antikoerper, rara2b antikoerper, wu:fj66e06 antikoerper, retinoic acid receptor alpha antikoerper, retinoic acid receptor, alpha antikoerper, retinoic acid receptor, alpha a antikoerper, retinoic acid receptor alpha L homeolog antikoerper, retinoic acid receptor, alpha b antikoerper, RARA antikoerper, Rara antikoerper, LOC100136372 antikoerper, raraa antikoerper, rara.L antikoerper, rara antikoerper, rarab antikoerper

Hintergrund:

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene: RARA

Molekulargewicht: 45kDa

Gen-ID: 5914

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteine