Cyclin D3 Antikörper (pThr283)
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- Target Alle Cyclin D3 (CCND3) Antikörper anzeigen
- Cyclin D3 (CCND3)
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Bindungsspezifität
- pThr283
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cyclin D3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- Phospho-Cyclin D3 (Thr283) Antibody detects endogenous levels of Cyclin D3 only when phosphorylated at Threonine 283.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human Cyclin D3 around the phosphorylation site of Thr283.
- Isotyp
- IgG
- Top Product
- Discover our top product CCND3 Primärantikörper
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anti-Cyclin D3 (CCND3) (AA 1-292) antibody
CCND3 Reaktivität: Human WB, ELISA, IHC, IP, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 121-220) antibodyCCND3 Reaktivität: Human, Kaninchen WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 136-292) antibodyCCND3 Reaktivität: Human, Ratte WB, FACS Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 252-281), (C-Term) antibodyCCND3 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB43029 unconjugated
anti-Cyclin D3 (CCND3) (AA 1-292) antibodyCCND3 Reaktivität: Human WB, PLA Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 1-292) antibodyCCND3 Reaktivität: Human WB, IHC (p), IF Wirt: Maus Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (C-Term) antibodyCCND3 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Schaf, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 1-292) antibodyCCND3 Reaktivität: Human WB, ELISA, IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin D3 (CCND3) (AA 33-66), (N-Term) antibodyCCND3 Reaktivität: Ratte WB Wirt: Kaninchen Polyclonal RB43404 unconjugated
anti-Cyclin D3 (CCND3) (pThr283) antibodyCCND3 Reaktivität: Human DB Wirt: Kaninchen Polyclonal RB42083 unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- Cyclin D3 (CCND3)
- Andere Bezeichnung
- CCND3 (CCND3 Produkte)
- Synonyme
- zgc:103502 antikoerper, CCND3 antikoerper, 9230106B05Rik antikoerper, AA682053 antikoerper, AL024085 antikoerper, AW146355 antikoerper, C78795 antikoerper, cyclin D3 antikoerper, ccnd3 antikoerper, CCND3 antikoerper, Ccnd3 antikoerper
- Hintergrund
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Description: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Gene: CCND3
- Molekulargewicht
- 31kDa
- Gen-ID
- 896
- UniProt
- P30281
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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