PKM Antikörper (pTyr105)

Produktnummer ABIN6255764

Produktdetails anti-PKM Antikörper

Target: PKM (Pyruvate Kinase M1/2 (PKM))

Bindungsspezifität: pTyr105

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-PKM2 (Tyr105) Antibody detects endogenous levels of PKM2 only when phosphorylated at Tyr105.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human PKM2 around the phosphorylation site of Tyr105.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PKM

Target: PKM (Pyruvate Kinase M1/2 (PKM))

Andere Bezeichnung: PKM (PKM Produkte)

Synonyme: CTHBP antikoerper, OIP3 antikoerper, PK3 antikoerper, PKM2 antikoerper, TCB antikoerper, THBP1 antikoerper, AA414905 antikoerper, AL024370 antikoerper, AL024424 antikoerper, Pk-2 antikoerper, Pk-3 antikoerper, Pk3 antikoerper, Pkm2 antikoerper, PKM12 antikoerper, CG7070 antikoerper, Dmel\\CG7070 antikoerper, PYK antikoerper, Pyk antikoerper, cb1029 antikoerper, fj33f03 antikoerper, pkm2 antikoerper, pkm2a antikoerper, wu:fj33f03 antikoerper, MGC53388 antikoerper, PKM antikoerper, PK-S antikoerper, pk3 antikoerper, pkm2b antikoerper, zgc:92037 antikoerper, pyruvate kinase M1/2 antikoerper, pyruvate kinase, muscle antikoerper, Pyruvate kinase antikoerper, pyruvate kinase M1/2a antikoerper, pyruvate kinase PKM antikoerper, pyruvate kinase (PK) antikoerper, pyruvate kinase antikoerper, pyruvate kinase M1/2 S homeolog antikoerper, pyruvate kinase M1/2b antikoerper, PKM antikoerper, Pkm antikoerper, PyK antikoerper, pkma antikoerper, pkm antikoerper, LOC710798 antikoerper, pyk antikoerper, pk antikoerper, LOC100534543 antikoerper, pkm.S antikoerper, pkmb antikoerper

Hintergrund:

Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Gene: EPHA2

Molekulargewicht: 58kDa

Gen-ID: 5315

UniProt: P14618

Pathways: Warburg Effekt