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CD247 Antikörper (pTyr142)

CD247 Reaktivität: Human, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6255812
  • Target Alle CD247 Antikörper anzeigen
    CD247 (CD247 Molecule (CD247))
    Bindungsspezifität
    • 16
    • 14
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr142
    Reaktivität
    • 95
    • 43
    • 19
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 71
    • 22
    • 5
    • 1
    Kaninchen
    Klonalität
    • 70
    • 29
    Polyklonal
    Konjugat
    • 54
    • 9
    • 8
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser CD247 Antikörper ist unkonjugiert
    Applikation
    • 73
    • 49
    • 31
    • 13
    • 12
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-CD3 zeta (Tyr142) Antibody detects endogenous levels of CD3 zeta only when phosphorylated at Tyr142.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human CD3 zeta around the phosphorylation site of Tyr142.
    Isotyp
    IgG
    Top Product
    Discover our top product CD247 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    CD247 (CD247 Molecule (CD247))
    Andere Bezeichnung
    CD247 (CD247 Produkte)
    Synonyme
    CD3-ZETA antikoerper, CD3H antikoerper, CD3Q antikoerper, CD3Z antikoerper, T3Z antikoerper, TCRZ antikoerper, 4930549J05Rik antikoerper, A430104F18Rik antikoerper, AW552088 antikoerper, Cd3 antikoerper, Cd3-eta antikoerper, Cd3-zeta antikoerper, Cd3h antikoerper, Cd3z antikoerper, Cd3zeta antikoerper, T3z antikoerper, Tcrk antikoerper, Tcrz antikoerper, LOC100136514 antikoerper, LOC100136549 antikoerper, LOC100305023 antikoerper, CD247 antikoerper, TCRzeta antikoerper, CD247 molecule antikoerper, CD247 antigen antikoerper, CD3zeta-2 antikoerper, CD3zeta-1 antikoerper, Cd247 molecule antikoerper, CD247 antikoerper, Cd247 antikoerper, cd3z antikoerper, cd247 antikoerper
    Hintergrund

    Description: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).

    Gene: CD247

    Molekulargewicht
    19 kDa
    Gen-ID
    919
    UniProt
    P20963
    Pathways
    T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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