ROCK2 Antikörper (pTyr722)

Produktnummer ABIN6256005

Produktdetails anti-ROCK2 Antikörper

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Bindungsspezifität: pTyr722

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROCK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: Phospho-ROCK2 (Tyr722) Antibody detects endogenous levels of ROCK2 only when phosphorylated at Tyr722.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human ROCK2 around the phosphorylation site of Tyr722.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ROCK2

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Andere Bezeichnung: ROCK2 (ROCK2 Produkte)

Synonyme: rocka-a antikoerper, xROK antikoerper, rock2 antikoerper, rok2 antikoerper, ROCK2 antikoerper, B230113H15Rik antikoerper, ROKalpha antikoerper, Rho-kinase antikoerper, Rock-II antikoerper, Rock2m antikoerper, mKIAA0619 antikoerper, ROCK-II antikoerper, ROK antikoerper, Rho-associated, coiled-coil containing protein kinase 2 L homeolog antikoerper, rho-associated, coiled-coil containing protein kinase 2a antikoerper, Rho associated coiled-coil containing protein kinase 2 antikoerper, Rho-associated, coiled-coil containing protein kinase 2 antikoerper, Rho-associated coiled-coil containing protein kinase 2 antikoerper, rock2.L antikoerper, rock2a antikoerper, ROCK2 antikoerper, Rock2 antikoerper

Hintergrund:

Description: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Gene: ROCK2

Molekulargewicht: 165kDa

Gen-ID: 9475

UniProt: O75116

Pathways: Microtubule Dynamics, WNT Signalweg, Tube Formation