SNAIL Antikörper (pSer246)
(1 reference)-
- Target Alle SNAIL (SNAI1) Antikörper anzeigen
- SNAIL (SNAI1)
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Bindungsspezifität
- pSer246
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SNAIL Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Phospho-SNAIL (Ser246) Antibody detects endogenous levels of SNAIL only when phosphorylated at Serine 246.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human SNAIL around the phosphorylation site of Ser246.
- Isotyp
- IgG
- Top Product
- Discover our top product SNAI1 Primärantikörper
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anti-SNAIL (SNAI1) (C-Term) antibody
SNAI1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 1-100) antibodySNAI1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 9-39), (N-Term) antibodySNAI1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB01400 unconjugated
anti-SNAIL (SNAI1) (C-Term) antibodySNAI1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) (N-Term) antibodySNAI1 Reaktivität: Human, Maus, Ratte, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) (AA 121-230) antibodySNAI1 Reaktivität: Human WB, ELISA, IF Wirt: Maus Monoclonal 2G11 unconjugated
anti-SNAIL (SNAI1) (AA 1-264) antibodySNAI1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 Reaktivität: Human, Maus, Ratte IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-SNAIL (SNAI1) antibodySNAI1 Reaktivität: Human ELISA Wirt: Maus Monoclonal 6D2 unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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: "Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis." in: Biomedicines, Vol. 9, Issue 10, (2021) (PubMed).
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: "Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis." in: Biomedicines, Vol. 9, Issue 10, (2021) (PubMed).
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- Target
- SNAIL (SNAI1)
- Andere Bezeichnung
- SNAI1 (SNAI1 Produkte)
- Synonyme
- SLUGH2 antikoerper, SNA antikoerper, SNAH antikoerper, SNAIL antikoerper, SNAIL1 antikoerper, dJ710H13.1 antikoerper, AI194338 antikoerper, Sna antikoerper, Sna1 antikoerper, Snail antikoerper, Snail1 antikoerper, SNAI1 antikoerper, BG:DS01845.1 antikoerper, CG3956 antikoerper, Dmel\\CG3956 antikoerper, Sco antikoerper, br28 antikoerper, br29 antikoerper, l(2)35Db antikoerper, l(2)br28 antikoerper, l(2)br29 antikoerper, l(3)br28 antikoerper, l35Db antikoerper, sn antikoerper, Xsnail antikoerper, sna antikoerper, snail1 antikoerper, xSna antikoerper, Snai antikoerper, sna2 antikoerper, snail2 antikoerper, cb643 antikoerper, sna-1 antikoerper, sna1 antikoerper, snai1 antikoerper, snail1a antikoerper, zgc:109820 antikoerper, snail family transcriptional repressor 1 antikoerper, snail family zinc finger 1 antikoerper, snail homolog 1 (Drosophila) antikoerper, snail antikoerper, zinc-finger transcription factor Snail antikoerper, snail family zinc finger 1 S homeolog antikoerper, protein escargot antikoerper, transcription factor protein antikoerper, snail zinc finger protein antikoerper, snail family zinc finger 1b antikoerper, snail family zinc finger 1a antikoerper, SNAI1 antikoerper, Snai1 antikoerper, sna antikoerper, snail antikoerper, snai1.S antikoerper, LOC410464 antikoerper, snai1b antikoerper, snai1a antikoerper
- Hintergrund
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Description: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Gene: SNAI1
- Molekulargewicht
- 29kDa
- Gen-ID
- 6615
- UniProt
- O95863
- Pathways
- Negative Regulation of intrinsic apoptotic Signaling
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