HNRNPC Antikörper (pSer260)

Produktnummer ABIN6256225

Produktdetails anti-HNRNPC Antikörper

Target: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Bindungsspezifität: pSer260

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-hnRNP C1/C2 (Ser260) Antibody detects endogenous levels of hnRNP C1/C2 only when phosphorylated at Serine 260.

Homologie: Horse,Rabbit,Dog,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human hnRNP C1/C2 around the phosphorylation site of Ser260.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HNRNPC

Target: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Andere Bezeichnung: HNRNPC (HNRNPC Produkte)

Synonyme: C1 antikoerper, C2 antikoerper, HNRNP antikoerper, HNRPC antikoerper, SNRPC antikoerper, MGC53243 antikoerper, HNRNPC antikoerper, bZ1G18.4 antikoerper, fb57h12 antikoerper, fi16b11 antikoerper, wu:fb57h12 antikoerper, wu:fi16b11 antikoerper, zgc:55701 antikoerper, AL022939 antikoerper, D14Wsu171e antikoerper, Hnrpc antikoerper, Hnrpc1 antikoerper, Hnrpc2 antikoerper, hnRNPC1 antikoerper, hnRNPC2 antikoerper, hnrnp-C antikoerper, hnRNP C antikoerper, hnrnp antikoerper, hnrpc antikoerper, snrpc antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog antikoerper, heterogeneous nuclear ribonucleoprotein C antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog antikoerper, HNRNPC antikoerper, hnrnpc.S antikoerper, hnrnpc antikoerper, Hnrnpc antikoerper, hnrnpc.L antikoerper

Hintergrund:

Description: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

Gene: HNRNPC

Molekulargewicht: 41kDa

Gen-ID: 3183

UniProt: P07910