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HNRNPC Antikörper (pSer260)

HNRNPC Reaktivität: Human, Ratte, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256225
  • Target Alle HNRNPC Antikörper anzeigen
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Bindungsspezifität
    • 17
    • 15
    • 12
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer260
    Reaktivität
    • 69
    • 47
    • 32
    • 8
    • 8
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 82
    • 2
    Kaninchen
    Klonalität
    • 73
    • 11
    Polyklonal
    Konjugat
    • 39
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HNRNPC Antikörper ist unkonjugiert
    Applikation
    • 48
    • 30
    • 30
    • 16
    • 14
    • 14
    • 13
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-hnRNP C1/C2 (Ser260) Antibody detects endogenous levels of hnRNP C1/C2 only when phosphorylated at Serine 260.
    Homologie
    Horse,Rabbit,Dog,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human hnRNP C1/C2 around the phosphorylation site of Ser260.
    Isotyp
    IgG
    Top Product
    Discover our top product HNRNPC Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))
    Andere Bezeichnung
    HNRNPC (HNRNPC Produkte)
    Synonyme
    C1 antikoerper, C2 antikoerper, HNRNP antikoerper, HNRPC antikoerper, SNRPC antikoerper, MGC53243 antikoerper, HNRNPC antikoerper, bZ1G18.4 antikoerper, fb57h12 antikoerper, fi16b11 antikoerper, wu:fb57h12 antikoerper, wu:fi16b11 antikoerper, zgc:55701 antikoerper, AL022939 antikoerper, D14Wsu171e antikoerper, Hnrpc antikoerper, Hnrpc1 antikoerper, Hnrpc2 antikoerper, hnRNPC1 antikoerper, hnRNPC2 antikoerper, hnrnp-C antikoerper, hnRNP C antikoerper, hnrnp antikoerper, hnrpc antikoerper, snrpc antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) S homeolog antikoerper, heterogeneous nuclear ribonucleoprotein C antikoerper, heterogeneous nuclear ribonucleoprotein C (C1/C2) L homeolog antikoerper, HNRNPC antikoerper, hnrnpc.S antikoerper, hnrnpc antikoerper, Hnrnpc antikoerper, hnrnpc.L antikoerper
    Hintergrund

    Description: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

    Gene: HNRNPC

    Molekulargewicht
    41kDa
    Gen-ID
    3183
    UniProt
    P07910
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