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Connexin 43/GJA1 Antikörper (pSer368)

GJA1 Reaktivität: Human, Ratte, Maus WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256297
  • Target Alle Connexin 43/GJA1 (GJA1) Antikörper anzeigen
    Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
    Bindungsspezifität
    • 20
    • 16
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer368
    Reaktivität
    • 125
    • 88
    • 83
    • 32
    • 11
    • 10
    • 10
    • 8
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 123
    • 7
    • 3
    • 1
    Kaninchen
    Klonalität
    • 126
    • 7
    Polyklonal
    Konjugat
    • 78
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert
    Applikation
    • 92
    • 51
    • 45
    • 22
    • 20
    • 16
    • 13
    • 13
    • 10
    • 9
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-Connexin 43 / GJA1 (Ser368) Antibody detects endogenous levels of Connexin 43 / GJA1 only when phosphorylated at Serine 368.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human Connexin 43 / GJA1 around the phosphorylation site of Ser368.
    Isotyp
    IgG
    Top Product
    Discover our top product GJA1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." in: Neurourology and urodynamics, (2018) (PubMed).

  • Target
    Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
    Andere Bezeichnung
    GJA1 (GJA1 Produkte)
    Hintergrund

    Description: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).

    Gene: GJA1

    Molekulargewicht
    43kDa
    Gen-ID
    2697
    UniProt
    P17302
    Pathways
    MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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