Lamin A/C Antikörper (pSer392)

Produktnummer ABIN6256311

Produktdetails anti-Lamin A/C Antikörper

Target: Lamin A/C (LMNA)

Bindungsspezifität: pSer392

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin A/C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-Lamin A/C (Ser392) Antibody detects endogenous levels of Lamin A/C only when phosphorylated at Serine 392.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Chicken,Xenopus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human Lamin A/C around the phosphorylation site of Ser392.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: LMNA (LMNA Produkte)

Synonyme: CDCD1 antikoerper, CDDC antikoerper, CMD1A antikoerper, CMT2B1 antikoerper, EMD2 antikoerper, FPL antikoerper, FPLD antikoerper, FPLD2 antikoerper, HGPS antikoerper, IDC antikoerper, LDP1 antikoerper, LFP antikoerper, LGMD1B antikoerper, LMN1 antikoerper, LMNC antikoerper, LMNL1 antikoerper, PRO1 antikoerper, Dhe antikoerper, 2459 antikoerper, 74/76 antikoerper, CG6944 antikoerper, D5 antikoerper, DM[[O]] antikoerper, Dm antikoerper, Dm(0) antikoerper, Dm0 antikoerper, Dm1 antikoerper, Dm2 antikoerper, DmLamin antikoerper, DmO antikoerper, Dm[[0]] antikoerper, Dm[[1]] antikoerper, Dm[[2]] antikoerper, Dm[[mit]] antikoerper, Dm[[o]] antikoerper, Dmel\\CG6944 antikoerper, Dmo antikoerper, LAM antikoerper, Lam Dm[[0]] antikoerper, Lam(Dm0) antikoerper, LamDm[[0]] antikoerper, LamDm[[o]] antikoerper, Lam[[Dm0]] antikoerper, Lamin Dm[[0]] antikoerper, jf27 antikoerper, l(2)04643 antikoerper, l(2)25Ec antikoerper, l(2)gdh-7 antikoerper, l(2)gdh7 antikoerper, l(2)jf27 antikoerper, lam antikoerper, lamDm0 antikoerper, lamDm[[0]] antikoerper, lamin antikoerper, lamin Dm0 antikoerper, lamin Dm[[0]] antikoerper, misg antikoerper, nlam antikoerper, cb948 antikoerper, fk66d12 antikoerper, wu:fk66d12 antikoerper, lmna-A antikoerper, fpl antikoerper, idc antikoerper, lfp antikoerper, cddc antikoerper, emd2 antikoerper, fpld antikoerper, hgps antikoerper, ldp1 antikoerper, lmn1 antikoerper, lmnc antikoerper, pro1 antikoerper, cdcd1 antikoerper, cmd1a antikoerper, cmt2b1 antikoerper, lgmd1b antikoerper, Lamin-A antikoerper, lamin-L(III)-like antikoerper, lamin A/C antikoerper, lamin A antikoerper, Lamin antikoerper, lamin A/C L homeolog antikoerper, lamin-L(III)-like antikoerper, LMNA antikoerper, Lmna antikoerper, Lam antikoerper, lmna antikoerper, lmna.L antikoerper, LMINA antikoerper

Hintergrund:

Description: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).

Gene: LMNA

Molekulargewicht: 74,65kDa

Gen-ID: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus