Merlin Antikörper (pSer518)
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- Target Alle Merlin (NF2) Antikörper anzeigen
- Merlin (NF2) (Neurofibromin 2 (NF2))
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Bindungsspezifität
- pSer518
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Merlin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Phospho-NF2 / Merlin (Ser518) Antibody detects endogenous levels of NF2 / Merlin only when phosphorylated at Serine 518.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human NF2 / Merlin around the phosphorylation site of Ser518.
- Isotyp
- IgG
- Top Product
- Discover our top product NF2 Primärantikörper
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anti-Neurofibromin 2 (NF2) (AA 477-576) antibody
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anti-Neurofibromin 2 (NF2) (AA 30-239) antibodyNF2 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-311) antibodyNF2 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 230-414) antibodyNF2 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reaktivität: Human WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 65-95), (N-Term) antibodyNF2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB19187 unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reaktivität: Human WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-507) antibodyNF2 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 19-595) antibodyNF2 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- Merlin (NF2) (Neurofibromin 2 (NF2))
- Andere Bezeichnung
- NF2 (NF2 Produkte)
- Synonyme
- ACN antikoerper, BANF antikoerper, SCH antikoerper, NF2 antikoerper, merlin antikoerper, zgc:194620 antikoerper, zgc:194631 antikoerper, NF2a antikoerper, nf2 antikoerper, neurofibromin 2 antikoerper, neurofibromin 2a (merlin) antikoerper, neurofibromin 2b (merlin) antikoerper, neurofibromin 2 (merlin) S homeolog antikoerper, NF2 antikoerper, Nf2 antikoerper, nf2a antikoerper, nf2b antikoerper, nf2.S antikoerper
- Hintergrund
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Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Gene: NF2
- Molekulargewicht
- 70kDa
- Gen-ID
- 4771
- UniProt
- P35240
- Pathways
- Cell-Cell Junction Organization
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